منابع مشابه
Digitoxin—A Critical Review *
Within recent years, there has been an increasing interest in purified digitalis preparations. However, in spite of the original optimistic reports , the recent literature tends to discredit the value of the new preparations. Most criticisms fall into two groups: (A) Inadequacy of digitali-zation with the original recommended dosage schedules. (B) Increase in the incidence of drug toxicity. It ...
متن کاملLarge-scale digitoxin intoxication.
Because of an error in the manufacture of digoxin tablets a large number of patients took tablets that contained 0.20 mg. of digitoxin and 0.05 mg. of digoxin instead of the prescribed 0.25 mg. of digoxin. The symptoms are described of 179 patients who took these tablets and suffered from digitalis intoxication. Of these patients, 125 had taken the faultily composed tablets for more than three ...
متن کاملAccumulation of 3H-digitoxin in CNS of cats with a hypersensitivity to the drug.
Considerable literature (1-6) is available on "the cumulative effect of digitalis", but the mechanism involved in the appearance of this "cumulative effect" is still a matter of speculation. Previous reports suggest the possibility that cardiac glycosides may produce their effects on the heart through the central nervous system (CNS) (7, 8). The present work was designed to determine whether "t...
متن کاملFluoroimmunoassay of digitoxin in serum.
This fluoroimmunoassay for digitoxin in serum involves use of a sheep antiserum to digitoxin coupled to magnetizable solid-phase particles and fluorescein-labeled 3-O-succinyl digitoxigenin as tracer. Sodium salicylate blocks binding of the drug by binding proteins, and endogenous fluorophores and other interfering components in serum samples are reliably and completely removed at the separatio...
متن کاملInterruption of the enterohepatic circulation of digitoxin by cholestyramine. I. Protection against lethal digitoxin intoxication.
Previous studies have demonstrated that considerable amounts of parenterally administered cardiac glycosides are excreted in the bile and reabsorbed across the intestinal mucosa in several species. It is currently believed that the more prolonged action of nonpolar digitalis glycosides is due to their retention and recycling in the enterohepatic circulation. This report describes studies carrie...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1982
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1982.tb01966.x